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scorpi_ местный житель
в ответ Simple 12.02.15 12:51
The GH/IGF-1 axis in ageing and longevity
Moreover, mice as well as humans with reduced activity of the GH/IGF-1 axis are protected from cancer and diabetes mellitus, two major ageing-related morbidities.
IGF System in Cancer
As such, several studies have demonstrated the association between circulating levels of IGF-1 and -II and cancer risk. In patients with acromegaly, [...] several studies have shown a 2-fold increased risk of gastrointestinal cancers [1–4]. Other studies have shown a modest association between higher circulating IGF-1 and -2 levels and an increased risk for prostate, breast, colorectal, and ovarian cancer [5–11]. The role of IGF in cancer risk is multifactorial and taken together, the preponderance of data suggests a slight increased risk of some cancers due to higher activity of the IGF system. Conversely, patients with congenital deficiencies in IGF-1 have a protective effect against developing cancer [22].
The key role of growth hormone — insulin — IGF-1 signaling in aging and cancer
Вообще говоря, стимуляция mTOR - основная цель в мышечной гипертрофии. Одновременно ингибирование mTOR - одно из основных направлений продления жизни. Продолжаем рекордно растить мясо?
Moreover, mice as well as humans with reduced activity of the GH/IGF-1 axis are protected from cancer and diabetes mellitus, two major ageing-related morbidities.
IGF System in Cancer
As such, several studies have demonstrated the association between circulating levels of IGF-1 and -II and cancer risk. In patients with acromegaly, [...] several studies have shown a 2-fold increased risk of gastrointestinal cancers [1–4]. Other studies have shown a modest association between higher circulating IGF-1 and -2 levels and an increased risk for prostate, breast, colorectal, and ovarian cancer [5–11]. The role of IGF in cancer risk is multifactorial and taken together, the preponderance of data suggests a slight increased risk of some cancers due to higher activity of the IGF system. Conversely, patients with congenital deficiencies in IGF-1 have a protective effect against developing cancer [22].
The key role of growth hormone — insulin — IGF-1 signaling in aging and cancer
Вообще говоря, стимуляция mTOR - основная цель в мышечной гипертрофии. Одновременно ингибирование mTOR - одно из основных направлений продления жизни. Продолжаем рекордно растить мясо?